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Funding Statement This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT (NRF-2018R1A2B3004266) and by the Technology Innovation Program (20012631, Development of BiConTech based oral protein pharmaceutical product technology), funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea)

It is possible that, in addition to factors such as reduced alcohol consumption, weight loss-related improvements in body image, or relief associated with better glycaemic control in diabetes, there may also be direct neurobiological mechanisms involved for example, through changes in the functioning of the brains reward system. It comes as a separate study examined accidental pregnancies among people taking GLP-1 receptor agonists during early pregnancy

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It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat