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The pattern was consistent across initial overdose type: patients whose first overdose involved alcohol had a 40% lower risk during active GLP-1 use, while those whose first overdose did not involve alcohol had a 37% lower risk

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While compounded alternatives gained traction when there were supply constraints, the FDAs intervention highlights the regulatory and evidentiary advantages of approved therapies including FDA-reviewed labeling, established safety and efficacy data, and regulated manufacturing oversight