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In a controlled study by Samsom and colleagues, healthy subjects given pramlintide showed gastric-emptying half-times that lengthened from about 112 minutes on placebo to roughly 169 minutes at 30 g and 177 minutes at 60 g a delay of more than an hour at the higher dose

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Consistently, in another study of ApoE / mice, anti-atherosclerotic effects of a liraglutide infusion included blocking uptake of oxidized LDL particles (potentially caused by a downregulation of the scavenger receptor CD36) and suppressing foam cell formation by reducing monocyte/macrophage infiltration in the aortic wall [45]