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To test the Photostability upon laser irradiation, 200 L of PLGA nanoparticles encapsulating DDA-GSH-AuNCs, Nile red or fluorescein were placed in UV 96-Well microplate and irradiated with the following lasers: (364 nm, 80 mW, 248 mW/cm 2 ), (568 nm, 30 mW, 93 mW/cm 2 ) and (488 nm, 30 mW, 93 mW/cm 2 ), respectively using confocal laser scanning microscope (LSM 510 META, Carl Zeiss MicroImaging GmbH, Gttingen, Germany) for total duration of 20 minutes

If chronic disease is the documented cause (rheumatoid arthritis, chronic infection, inflammatory bowel disease), D63.8 applies