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A recent study found that the ferroptosis inducer erastin can induce cellular autophagy, and autophagy can trigger ferroptosis by degrading ferritin and transferrin receptor 1 (TfR1), resulting in the accumulation of intracellular iron

Gut 42:830835 Portincasa P, Peeters TL, van Berge-Henegouwen GP, van Solinge WW, Palasciano G, van Erpecum KJ (2000) Acute intraduodenal bile salt depletion leads to strong gallbladder contraction, altered antroduodenal motility and high plasma motilin levels in humans

KEAP1 cysteine oxidation then stabilizes NRF2 to allow its nuclear translocation, but chronic infection dysregulates this pathway, permitting ROS accumulation

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