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Furthermore, GHK-Cu's role as a cofactor for the antioxidant enzyme superoxide dismutase (SOD) is complemented by its apparent ability to increase the expression of other antioxidant genes, providing a multi-pronged mechanism for investigating oxidative stress mitigation in cell-based assays

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Overall, these findings collectively demonstrate that the molecular ruthenium catalyst Ru(II)-OH and the nanoparticle formulation NP2 are therapeutically active in a 21% O 2 atmosphere, but these lose their therapeutic efficiency in a 1% O 2 atmosphere