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Additionally, LONP1 knockdown activates the nuclear factor erythroid 2-related factor 2 (Nrf2)/Keap1 signaling pathway and upregulates glutathione peroxidase 4 (GPX4), thereby reversing erastin-induced ferroptosis in pancreatic cancer cells [159]

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It also provides a focused discussion of emerging approachesincluding postbiotics, probiotictraditional Chinese medicine (TCM) combinations, targeted delivery systems, and fecal microbiota transplantation (FMT)providing a conceptual framework and new directions for developing effective, durable next-generation microecological therapies