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Concurrently, vitamin B12 deficiency was identified as a significant public health concern, particularly among vulnerable populations such as the elderly and developing embryos, where insufficient B12 levels have been associated with an increased risk of neural tube defects

However, their response might be unpredictable and result in relapse hyperpigmentation (Hofbauer Parra et al., 2016

It is thought that hormonal changes such as this hypocortisolism may result in symptoms of fatigue experienced by patients (255, 428, 429)

Deficiencies in DCX expression or function are associated with severe neurodevelopmental disorders, such as lissencephaly and subcortical band heterotopia