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While L-Carnitine can be taken as a capsule or powder, the liquid form offers faster absorption and more efficient utilization by the body, ensuring that your muscles and cells receive the energy they need exactly when you need it

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This design choice introduces potential bias, particularly for subjective outcomes, but it reflects the practical reality that these treatments have different injection devices and titration schedules that would make blinding extremely difficult

Despite the increase in the global burden of SCD, which is believed to affect over 20 million people [32], including an estimated 200,000 annual sickle genotype births in Sub-Saharan Africa [33], available data on SCA prevalence, morbidity, and mortality remains limited on a global scale