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1), GLP-1Rs have subsequently been localised to the central and peripheral nervous system, lung, kidney, gastrointestinal tract, heart and blood vessels [3], where they mediate a diverse number of actions distinct from control of glucose homeostasis [4]

This process is governed by BCL2 family proteins, including the pro-apoptotic BCL2 associated X, apoptosis regulator (BAX) or BCL2 antagonist/killer 1 (BAK1, also known as BAK) as well as anti-apoptotic members, such as BCL2 apoptosis regulator (BCL2) and BCL2 like 1 (BCL2L1, also known as BCL-XL)