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Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: how can the formulation make a difference

Pfizer deployed the AG strategy aggressively after Lipitor lost exclusivity in November 2011

Since GSH is the final product of the homocysteine metabolism in the transsulfuration pathway by transferring sulfur from homocysteine to cysteine, a deficiency in transsulfuration pathway leads to excessive homocysteine production (hyperhomocysteinemia) and reduced GSH synthesis (159, 160)

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