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Clinical Studies with IGFS and IGFBPs Recombinant human IGF-I (rhIGF-I) has been used with success to treat GH resistance and IGF-I deficiency syndromes in children, although clinical use is not widespread, in part because of metabolic adverse effects including hypoglycemia and hypophosphatemia

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[13] How the evidence for IGF-1 LR3 compares to native IGF-1 A useful calibration is to contrast the two evidence bases directly