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When to Contact Your Prescriber Contact your prescribing clinician if you experience any of the following while taking Ozempic and a PPI together: persistent vomiting lasting more than 48 hours (may signal gastroparesis requiring evaluation), return of reflux symptoms that were previously well controlled on a stable PPI dose, signs of B12 deficiency such as numbness, tingling, or unexplained fatigue after 6 or more months of combined use, or if you are starting or stopping any medication with a narrow therapeutic index such as warfarin, lithium, or phenytoin

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