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Clinical studies Compared with the considerable amount of pre-clinical and mechanistic research reported above, we identified few clinical studies of GLP-1RAs for substance-use disorders (Table 2): three for alcohol 111,112,113 , one for cannabis 114 , two for cocaine 115,116 and two for nicotine 117,118 , while no article about opiates or amphetamines was retrieved
To alleviate symptomatology, the following measures are advisable [29]: Comply with recommendations regarding intake habits and food composition (Table 2, Figure 1, Figure 2 and Figure 3)
Notably, the percentage of patients discontinuing treatment escalates significantly when initial weight loss results fail to meet expectations