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Another aspect of the invention is that sequential administration of low doses of a PDE-5 inhibitor and PT-141 for treatment of sexual dysfunction provides a therapeutic effect equal or superior to administration of a high dose of any one single agent without the side effects attendant to administration of a high dose of any one single agent

After extensive research and clinical trials with over 5.000 participants

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Results from a blood-oxygen dependent functional MRI study [44] also suggest that mesolimbic reward-related areas may also mediate the anorectic effects of Ex in humans, with a hypothesised mechanism of decreasing responsiveness to contextual food cues (incentive salience, wanting) and increasing activity that correlates with consummatory reward value (liking) [45]