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Thus, NACs neuroprotective effects may involve its ability to reduce cortical spermidine levels and thereby limit local excitotoxic effects in the PFC during THC exposure, further indicated by our electrophysiological findings demonstrating a hyperactive neuronal mPFC phenotype

A 3 mg/kg SC dose of the peptide decreased food intake in rats by 47% percent in the first seven hours following administration and 34% after 48 hours

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