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Hashemi 2009: The Founding T2DM Trial Hashemi 2009 is widely cited as a foundational RCT of milk thistle in type 2 diabetes, with the trial using 140 mg silymarin three times daily versus placebo over 4 months in T2DM patients

A 2023 study published in Pharmaceuticals (Basel) found that it may help with brain-gut axis repair and function ( 9 )

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BPC-157s safety profile appears favorable based on animal trials