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The average weight loss with Wegovy injection was 14.9% (34.6 lb / 15.7 kg) from a starting weight of 232 lb (105 kg) after 68 weeks in the STEP 1 clinical trial (NCT03548935), compared with 2.4% (5.5 lb / 2.5 kg) with placebo

[17] [18] This rapid degradation necessitates the development of modified GLP-1 analogues or DPP-4 inhibitors to achieve sustained therapeutic effects

Joint-specific nutrients: Glucosamine and chondroitin for cartilage (evidence mixed but safe and inexpensive)

A study published in Nature found that over four years, patients taking semaglutide lost an average of 10.2% of their body weight, whereas those on a placebo lost only 1.5%