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Kobayashi A, Valerius MT, Mugford JW et al (2008) Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development
No improvement was seen in OS or PFS for the temozolomide group, and this dose and schedule resulted in more toxicity than standard-dose, single-agent dacarbazine.[48][Level of evidence A1] Two randomized phase III trials in previously untreated patients with metastatic melanoma (resulting in FDA approval for vemurafenib [21] and ipilimumab [6]) included dacarbazine as the standard therapy arm
Monitoring: Symptom tracking (nausea frequency, vomiting episodes, ability to tolerate solid food, early satiety severity) should be documented weekly
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