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Inflammatory cytokines cleave the N-terminal sequence of GSDMD, and this fragment binds to the cell membrane, forming pores and inducing cell rupture, ultimately leading to pyroptosis [95, 96]

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Chronic respiratory diseases (CRDs) are a major public health issue, in 2019 ranked as the third leading cause of death, 454.6 million prevalent cases and with 4.0 million deaths across the world ( Momtazmanesh et al

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