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For instance, sequence remodeling and extension led to the discovery of exenatide (Byetta), a 39-amino acid synthetic peptide with 50% sequence identity to GLP-1, derived from exendin-4, a peptide found in the venom of the Gila monster Heloderma suspectum (Van Baelen et al., 2022)

Toxic doses in research have been measured at 300-3,750 times higher than therapeutic ranges, providing substantial safety margins

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