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Ilanges, A

The amylin receptor agonist class, which includes cagrilintide, adds a second mechanism of action that strengthens the weight loss effect

In patients with T2D 10% weight loss induced by RYGB has shown to lower fasting endogenous glucose output compared to those who achieved similar weight loss by calorie restriction only [15], suggestive of a weight-loss independent effect of RYGB on hepatic glucose metabolism

The next generation of the drugs, to me, would be coming up with the recipe where we can actually utilize what we have learned already to balance the benefit and complications to a much better degree, Salehi said