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Therefore, it seems very important to take these aspects into account in the coexistence of HT and PCOS

EVs promote the proliferation, migration, and invasion of endometrial stromal cells (ESCs), inhibit ESCs apoptosis, and enhance the progression of endometriosis and angiogenesis by regulating the miR-761/histone deacetylase 1 (HDAC1) axis and activating the signal transduction and activator of transcription 3(STAT3)-mediated inflammation (Zhang et al., 2022)

These issues are frequently compounded by the intrinsic physicochemical limitations of PROTACs, such as poor membrane permeability, further complicating their delivery and efficacy