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4a, compared with OA group, the body weight of rats in OA + saline had no significant change at 0 day ( P = 0.9993), 7th day ( P = 0.8538), 14th day ( P = 0.5209), 21st day ( P = 0.3575) and 28th day ( P = 0.8092) after treatment with saline, which indicated that saline could not induce weight loss