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Cell culture studies using adipocytes have shown that NNMT overexpression promotes lipid accumulation and insulin resistance, while NNMT knockdown or inhibition increases NAD+ levels, activates SIRT1, enhances mitochondrial respiration, promotes expression of thermogenic genes including UCP1, and drives white adipocyte browning toward a beige phenotype

The combination may result in more severe or prolonged gastrointestinal symptoms, potentially leading to dehydration, electrolyte imbalances, or nutritional deficiencies if food intake becomes severely restricted

Wu Y, Zhang M, Meng F, Ren K, Li D, Luo X, et al

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