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STELARA is a prescription biologic medicine Many biologics are made from proteins, genes, or antibodies Some biologics target enzymes or proteins that may cause inflammationlike the inflammation thought to cause ulcerative colitis symptoms STELARA works differently There are many different naturally occurring proteins in the body that contribute to inflammation

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However, mutating the peptide at position W25 when in light chain fusion with the anti-PCSK9 Ab#2 resulted in peptide truncation during production except for the W25K variant

doi: 10.1097/00003246-200107000-00002 240 LaszloITrasyDMolnarZFazakasJ