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In a rodent model, a novel GLP-1R/GIPR/GCGR triple agonist, SAR441255, has been shown to promote weight loss and the maintenance of healthy blood glucose levels and is superior to the GLP-1R/GCGR dual agonist (Saxena et al., 2023)

The following section extends this analysis to appetite, satiety, and behavioral peptides, where similar dynamics have constrained progress despite strong physiological validation

Weve talked about on a previous episode, I think it was the episode where we talked about no non-responders to resistance type exercise

Further reading [edit] "People Are Already Taking This Unapproved New Weight-Loss Drug"