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The primary concern relates not to direct drug interactions between most injectable GLP-1 agonists and levothyroxine, but rather to the potential impact on thyroid monitoring and the theoretical risk associated with thyroid C-cell tumours observed in animal studies

Furthermore, treatment with anti-PD-1 may first produce only a latent inflammatory involvement associated to dysregulated cardiac metabolism that may progress to overt myocarditis in a subset of patients (200, 201)