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Future directions to overcome these challenges include biomarker-driven clinical trials that enrich enrollment with patients exhibiting high mtDAMPs or immune dysfunction, such as testing NLRP3 inhibitors in cardiac surgery patients with elevated preoperative neutrophilplatelet aggregates or high mtDNA levels after CPB, thereby increasing the power to detect benefits in those most likely to respond

Excessive fat mass in PWS typically affects the trunk and the proximal extremity of the limbs

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Phase 3 trial just published in NEJM for #orforglipron, an oral GLP-1 medication for obesity