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25,26 The deposition of large amounts of extracellular matrix by fibroblasts during reparative fibrosis can serve to replenish what was lost during the degeneration of IVDs and can contribute to the maintenance of disc height
FIGURE 3 GO and KEGG analyses of the 59 aforementioned candidate targets indicated that the biological process (BP) terms of the target genes were mainly involved in the positive regulation of cell proliferation (GO:0008284), protein phosphorylation (GO:0006468), positive regulation of cell migration (GO:0030335), and negative regulation of apoptosis (GO:0043066)
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In addition, if we make manufacturing or formulation changes to our product candidates, we may need to conduct additional testing to bridge our modified product candidate to earlier versions
