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To understand the effectiveness of GLP-1 receptor agonists, its helpful to look at how GLP-1 hormones function in the body: GLP-1 is a hormone produced in the gut that helps regulate blood sugar and appetite

What Endocrinologists and Obesity Medicine Specialists Say The Endocrine Society's 2023 clinical practice guideline on obesity pharmacotherapy states: "Pharmacotherapy for obesity should be considered an adjunct to comprehensive lifestyle intervention, not a replacement for it." The full guideline is accessible through the Endocrine Society's journal

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This increases the likelihood of an accidental overdose and serious side effects, as these medications are potent and have doses in milligrams