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GLP-1s: The Weight Loss Drug Thats NOT Just About Weight We will discuss new literature in Science & Cell Metabolism about GLP-1 receptor agonists, inflammation, the brain and overall health

Causes Metabolic Diabetes mellitus (most common cause) diabetic neuropathy Hypothyroidism Vitamin deficiencies (B1, B6, B12, E) Infectious HIV, leprosy Hepatitis B or C Herpes zoster Toxic / Drug-Induced Chemotherapy (e.g., platinum compounds, paclitaxel) Alcohol Heavy metals (lead, arsenic) Autoimmune / Inflammatory Guillain-Barr syndrome Chronic inflammatory demyelinating polyneuropathy (CIDP) Genetic Charcot-Marie-Tooth disease Other Chronic kidney disease Trauma or compression (carpal tunnel syndrome) Clinical Features Sensory Symptoms Numbness, tingling, pins and needles (paresthesia) Burning, stabbing, or shooting pain Loss of vibration, temperature, or proprioception Usually symmetrical and distal (stocking-glove pattern) Motor Symptoms Weakness Muscle wasting (atrophy) Loss of reflexes Autonomic Symptoms Orthostatic hypotension Gastrointestinal motility problems (constipation/diarrhea) Bladder dysfunction Abnormal sweating Investigations Blood tests: Blood sugar, vitamin B12, thyroid function, renal/liver function Nerve conduction studies / EMG: Assess type and severity of neuropathy Imaging: Only if compressive lesion suspected Lumbar puncture: In inflammatory neuropathies like GBS Management 1

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