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Most patients notice reduced appetite within the first few weeks

A slower or incomplete absorption event doesn't just mean a slightly lower peak it means your entire week of appetite suppression and blood sugar regulation could run below optimal levels

The absolute risk per patient remains modest, but the very large and growing number of people on these medications means the absolute number of patients presenting with biliary complications is substantial and rising

However, while central pharmacodynamics is an important factor influencing drug intake, peripheral pharmacokinetics can also have a profound effect on intake and even neural response to the same drug 56,57