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By the 12 to 16-week mark, many individuals experience the full effects, which can include a significant reduction in body weight, often around 5% to 10% or more of their starting weight

GLP-1 receptor agonists, developed initially as diabetes medications, have gained popularity due to their ability to suppress appetite and reduce the speed of gastric emptying, resulting in weight loss (5)

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This combination, lowering the reward and lowering the unease, may explain why many users report reduced cravings without significant effort