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Wilfrid James Loughlin published two papers in 1932, in which the effect of denaturation on the viscosity of protein solutions was analyzed and demonstrated that the unfolding of proteins increases the viscosity of their solutions, resulting in an increase in protein volume (Loughlin, 1932

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Instead of engaging in a direct debate on real-world safety or patient outcomes, the agency pivoted to a foundational question: What, precisely, is BPC-157? By highlighting a lack of standardized USAN nomenclature, USP monographs, and unified salt definitions, the FDAs message was clear: We cant create quality standards or evaluate safety unless we actually know what it is