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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, Steffes M

Proc Natl Acad Sci 100(20):1120711210

Enzyme replacement therapy has achieved remarkable curative effects by enhancing the decomposition of glycosphingolipids in lysosomes, relieving the pressure on lysosomes, and improving lysosomal function 123