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N Engl J Med 392(6):612615 [DOI] [PubMed] [Google Scholar] 28.Rosenstock J, Frias J, Jastreboff AM, Du Y, Lou J, Gurbuz S, Thomas MK, Hartman ML, Haupt A, Milicevic Z, Coskun T (2023) Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA

The MDS-UPDRS and CDR-SB cannot cleanly separate symptomatic relief from disease modification, and EVOKE showed the converse failure mode, biomarker movement without clinical benefit, so future trials should anchor on objective measures such as dopamine-transporter SPECT, neurofilament light chain, and tau, amyloid, and neuroinflammation PET

(You know youre in for a long day when an Excel file comes with its own Users Manual!) The ICE_Model spreadsheet contains a little more than 25 tabs, all of which require major brain power

Gene expression analysis Total RNA was extracted using RNeasy (Qiagen