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Also, an enhanced selection criterion to identify patients with advanced-stage cancers who will or will not benefit from ICI agents is essential, and the need to involve early primary palliative care for the potential non-responders

Optimal Exercise Intensity and Duration Moderate-intensity exercise (60-75% of maximum heart rate) for 30-60 minutes typically provides optimal hormetic stimulation of antioxidant defenses without causing excessive oxidative stress that overwhelms cellular protective systems

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