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As it doesnt have FDA approval, it may have limited availability

For example, In the United States, a multi payer model exists when it comes to drug pricing regime, which is currently undergoing significant changes, with recent federal legislation, such as the Prescription Drug Pricing Reform provisions of the Inflation Reduction Act, significantly altering the pricing regime under certain federal programs

Retinopathy worsening has been observed in diabetic patients with severe baseline vision changes, though causation remains unclear and may relate to rapid glucose fluctuations rather than the drug itself

Sterile vials are manufactured under strict pharmaceutical standards, but once expired, the manufacturer no longer guarantees that the solution remains free of bacteria and contaminants