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Disruption of oxidative homeostasis in the cardiovascular system can lead to oxidative stress, causing cellular damage and cardiovascular disease (38)

Finally, emerging clinical observations such as progression independent of relapse activity and silent progression, now thought to take hold very early in the course, together argue that an underlying cytodegenerative process, likely targeting the myelinating unit, may in fact represent the most proximal step in a complex pathophysiological cascade exacerbated by an autoimmune inflammatory overlay

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doi: 10.3390/nu15081929 383 PieczykolanAPietrzakWGawlik-DzikiUNowakR