glp-1/gip/glucagon triple agonist The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor tirzepatide: a novel cardiometabolic therapeutic prospect | Cardiovascular Diabetology 🎙️ NEW EPISODE: Retatrutide—The Triple

Sample size calculations were based on phase 2 trial data, which predicted a treatment difference of 1.0 in the Female Sexual Function Index-desire domain (FSFI-D) score and about 20.43 points in the Female Sexual Distress Scale-Desire/Arousal/Orgasm (FSDS-DAO) item 13, with a total of 450 evaluable patients providing sufficient statistical power to detect significant differences

doi: 10.1073/pnas.91.11.4673 208 MarkwalderRReubiJC

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The pocket volumes of inactive (GLP-1RFab7F38), active-like (GLP-1Rpeptide 5), and active (GLP-1RGLP-1Gs) structures were calculated with POVME 35