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, accompanied by reduced mitochondrial content, membrane potential hyperpolarization, and enhanced glycolysis, revealing that intercellular interactions induce metabolic reprogramming by remodeling the metabolic microenvironment ( 2.2.2 Key metabolites and signaling pathways A variety of key metabolites and signaling pathways play important regulatory roles in the process of metabolic remodeling in PH
From the proteins perspective: MRP1 and MRP7 share three residues that interact with all the drugs: M339, I591, and T1241 in MRP1 correspond to G299, M546, and T1195 in MRP7 (Table 1, dark gray)
Accordingly , these activities do not include clinical, therapeutic, or diagnostic use
