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Enhance insulin secretion Stimulates insulin release only when blood glucose is high

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Retatrutide is an investigational triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors

Semaglutide (Ozempic for diabetes, Wegovy for weight management) and tirzepatide (Mounjaro, licensed for type 2 diabetes in the UK)a dual GLP-1/GIP receptor agonistare highly effective but are associated with gastrointestinal side effects that are dose-dependent