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While the majority of the Rossmann and globin binding domains are relatively unperturbed, the N-terminal four helix bundle adapts to the removal of the adenosine through changes in the position of the Glu71/His72 containing helix

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Alzheimers disease AD is a progressive neurodegenerative condition identified by the presence of amyloid- plaques and tau neurofibrillary tangles in the central nervous system [114]