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Reassess before any escalation: A dose increase should follow a protocol need and a review of prior observations

The mechanisms underlying this age-related NAD+ depletion involve multiple factors, including increased consumption by DNA repair enzymes, reduced biosynthesis, and enhanced degradation by CD38 and other NAD+-consuming enzymes

A double-blind, placebo-controlled trial in 90 HIV-positive patients with symptomatic distal symmetrical polyneuropathy found no benefit of intramuscular injection with 1 g/day of ALCAR for two weeks in the intention-to-treat analysis, but there was some pain relief in the group of 66 patients who completed the trial (84)

These nutrients play a crucial role in maintaining the health and function of the nervous system