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Strategies to Minimize Weight Rebound if You Pause or Stop If you must temporarily pause semaglutide for medical reasons, several evidence-based strategies reduce rebound: maintain high protein intake (which provides natural satiety), prioritize structured meal timing to prevent grazing, increase physical activity to offset the metabolic slowdown, and ensure adequate sleep (poor sleep amplifies hunger hormones)

Rising estrogen on HCG is normal but requires attention if symptoms develop or levels climb excessively

[PubMed] [Google Scholar] 47.Handy D.E., Loscalzo J

Monitoring by a healthcare provider is essential