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Females taking spironolactone may experience menstrual irregularity, including postmenopausal bleeding, breast tenderness or mastalgia, hirsutism, deepened voice, and amenorrhea

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Deficiencies may manifest as neurological symptoms, including numbness, tingling, and cognitive disturbances

Across the United States, the prevalence of past-month cannabis use in the older population has increased, with significant growth observed across multiple demographic subgroups and chronic medical conditions, such as chronic pain, cancer, COPD, anxiety, posttraumatic stress disorder (PTSD), and sleep disorders (Han et al., 2025