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Abbreviations: apo apolipoprotein BMI body mass index BP blood pressure CV cardiovascular CVD cardiovascular disease FDA Food and Drug Administration FPG fasting plasma glucose GIP gastric inhibitory polypeptide GLP-1 glucagon-like peptide 1 GLP-1 RA GLP-1 receptor agonist HbA1c hemoglobin A1c HF heart failure kcal kilocalories kg/m kilograms per square meter LEAD liraglutide efficacy and action in diabetes MACE major adverse cardiovascular events mg milligrams MI myocardial infarction NAFLD nonalcoholic fatty liver disease NASH nonalcoholic steatohepatitis Ozempic Brand name for injectable semaglutide for type 2 diabetes management P = probability value ( P value) SCALE Satiety and Clinical Adiposity-Liraglutide Evidence SELECT Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity STEP Semaglutide Treatment Effect in People with Obesity T2DM type 2 diabetes mellitus Wegovy Brand name for injectable semaglutide for weight management The authors have no funding and conflicts of interest to disclose

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The program starts July 1, 2026, and is scheduled to end December 31, 2027