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doi: 10.1016/j.beem.2020.101388 2

These groups Women who are pregnant or breastfeeding: There is little information about how semaglutide can affect your baby while youre pregnant or breastfeeding, but animal studies show that the risk of birth defects is considerable

The available animal studies were not sufficient to resolve this concern because they did not provide a comprehensive dose-ranging, long-term carcinogenicity programme

In circulation, the bioavailability of native IGF-1 is tightly regulated by a family of six IGF binding proteins (IGFBP-1 through IGFBP-6), which sequester ~99% of plasma IGF-1 and limit its receptor-accessible fraction