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Agents such as liraglutide (3.0 mg daily) and once-weekly semaglutide have been approved for obesity treatment, achieving weight reductions of approximately 515% in many patients Highdose GLP-1RAs significantly reduce body weight by suppressing appetite and calorie intake [234]
These conditions require careful symptom review, trigger assessment, medication review, and sometimes specialist collaboration
Louis and Burlington, MA), and a single-stranded oligodeoxynucleotide (ssODN) (IDT Coralville, Iowa, USA) containing homology arms and carrying the K216E mutation
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